A new way to stabilize temperature-sensitive molecules during storage, transport and use.
What is NanoShield?
NanoShield is a revolutionary type of additive (or excipient) that can extend the temperature-controlled shelf life of unstable molecules and potentially completely eliminate the need for temperature controlled storage for some.
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NanoShield is a proprietary, PEG-based excipient that encapsulates molecules in a hydrogel matrix shielding from forces that cause degradation.
At the point of use, molecules are released from NanoShield by photo-triggered degradation of the hydrogel by exposure to a specific wavelength of benign, low-intensity light for a short period of time.
After release, all that remains is soluble PEG and the cargo molecule now ready for use.
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NanoShield may be applied to:
Biologics (Antibody Therapeutics, Protein Therapeutics, Vaccines)
The Problem
- Biologics are the fastest growing class of new drugs that allow the treatment of diseases never before possible.
- Antibodies, recombinant proteins, vaccines, etc. are often unstable and very sensitive to extreme temperatures.
- Biologics require refrigeration during development, manufacturing, storage and transportation.
The NanoShield Solution
- NanoShield can increase the stability of biologics such as therapeutic antibodies, proteins therapeutics and vaccines.
- NanoShield enables drugs to tolerate exposure to elevated temperatures, freezing and agitation.
- Increased biologic stability allows for:
- Reduced product loss
- Decreased cost
- Simplified mail delivery of drugs for patients
- Access for patients in the developing world
Specimens for Diagnostics
The Problem
- Life-saving medical diagnostics require high-quality biological samples such as blood, saliva and urine
- Critical protein biomarkers in the samples can rapidly degrade without temperature-controlled storage and transport
- Degradation can compromise the accuracy of diagnostic analyses
The NanoShield Solution
- Protein biomarkers within biological samples stored with NanoShield will have increased stability
- Increased biological sample stability allows for:
- Reduced costs associated with sample processing
- More accurate and reliable diagnostics used to inform medical treatments and save lives
Reagents used in Biological Research
The Problem
- Protein-based research reagents such as antibodies, enzymes and recombinant proteins are vital for biological research
- Many research-grade products are extremely temperature labile
- Currently, most products require complicated and expensive dry ice packaging during shipping
- Product loss is common, expensive and is an unnecessary bottleneck for critical scientific discoveries
The NanoShield Solution
- Formulation with NanoShield will stabilize research reagents, allowing for:
- Decreased cost
- Simplified shipping logistics
- Reduced product loss due to temperature exposure
- Accelerated scientific research
Industrial Enzymes
The Problem
- Protein-based industrial reagents such as enzymes are widely used in a great variety of manufacturing applications
- Enzymes are sold based on activity; it is important to both producer and customer that they retain activity during storage
- Efficient storage often requires expensive temperature controlled environments
- Loss of enzymatic potency during storage can greatly impact costs associated with manufacturing
The NanoShield Solution
- Formulation with NanoShield allows for:
- Alleviated need for expensive temperature controlled storage
- Reduce potency loss
- Reduced materials costs
- Improved efficiency for manufacturing processing requiring these expensive reagents
